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Displaying 1-5 of 14 results for: lc-ms

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Intact mass analysis of monoclonal antibody charge variants by multi heart-cut 2D-LC/MS coupling ion-exchange and reversed-phase chromatography

Instrument Type: LCMS

Multiple heart-cut 2D-LC-MS is an efficient approach for charge variant analysis of antibodies by enabling direct MS analysis of first dimension ion-exchange fractions after desalting in the second dimension. Intact mass analysis facilitates identification and monitoring of mAb charge variant patterns. Annotations of major and minor charge variant peaks could be proposed. Enrichment of one fraction was used to improve the MS signal intensity.

development a stabilityindicating method for esomeprazole related degradation products by automated method scouting mass detection

Development of a stability-indicating method for esomeprazole and related degradation products by automated method scouting and mass detection

Instrument Type: LCMS

Demonstrate a streamlined method scouting workflow for the analysis of esomeprazole and related degradation products.

complementary analysis a biopharmaceutical research laboratory with a 2dlcms instrument for flexible operation

Complementary analysis in a biopharmaceutical research laboratory with a 2D-LC-MS instrument for flexible operation

Instrument Type: LCMS

The application note describes an efficient approach for identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC-MS in a top-down experiment. In addition the Thermo Scientific™ Simple Switch™ technology enables the instrument to be used in multi heart-cut 2D-LC-MS, 1D-LC-MS, or Dual 1D-LC mode for the most flexible equipment and lab space utilization and maximum MS productivity.

increase sensitivity uhplcms analysis by minimizing postcolumn dispersion

Increase sensitivity in UHPLC-MS analysis by minimizing post-column dispersion

Instrument Type: LCMS

Reduce post-column dispersion with small ID capillaries for fast gradient UHPLC-MS methods using sub-2 μm particle next-generation columns

forceddegradation evaluation erythromycin by hplc single quadrupole mass spectrometry

Forced-degradation evaluation of erythromycin by HPLC and single quadrupole mass spectrometry

Instrument Type: LCMS

Simple stability-indicating LC-MS method for erythromycin. Compare the impurity profiles of an erythromycin reference standard with stressed analyte.

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